Randomized comparison of early supplemental oxygen versus ambient air in patients with confirmed myocardial infarction: Sex-related outcomes from DETO2X-AMI

The purpose of this study is to investigate the impact oxygen therapy on cardiovascular outcomes in relation sex patients with confirmed myocardial infarction (MI). DETermination role Oxygen suspected Acute Myocardial Infarction trial randomized 6,629 at 6 L/min for 6-12 hours or ambient air. In present subgroup analysis including 5,010 (1,388 women and 3,622 men) MI, we report effect supplemental composite all-cause death, rehospitalization heart failure long-term follow-up, stratified according sex. Event rate endpoint was 18.1% allocated oxygen, compared 21.4% air (hazard ratio [HR] 0.83, 95% confidence interval [CI] 0.65-1.05). men, incidence 13.6% 13.3% (HR 1.03, CI 0.86-1.23). No significant interaction found (P= .16). Irrespective treatment, occurred more often men (19.7 vs 13.4%, HR 1.51; CI, 1.30-1.75). After adjustment age alone, there no difference between sexes 1.06, 0.91-1.24), which remained consistent after multivariate adjustment. normoxemic MI did not significantly affect mortality men. observed worse outcome explained by differences baseline characteristics, especially age.